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The long-term safety of semaglutide is a critical consideration for both patients and healthcare providers, given that obesity and type 2 diabetes are chronic conditions requiring ongoing management

These findings are generally attributed to weight loss and improved metabolic status rather than direct thyroidal effects, although the underlying mechanisms remain unclear

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Women made up 56% of the Phase 2 trial cohort (89 out of 157 participants at the 12mg dose)

Muscle wasting in the context of T2D and obesity represents not only a complication but also a driver of disease progression, contributing to diminished insulin sensitivity, reduced physical capacity and adverse outcomes [3]

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