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First cardiovascular safety trial of a DPP-4 inhibitor in patients with T2DM and high cardiovascular risk, showing that saxagliptin does not augment MACE but increases hospitalization for heart failure

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doi: 10.1111/obr.13428, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 35

Both Nirchi and Long point to things like nausea and constipation, particularly when starting the drugs or titrating up to a higher dose (but for them, the benefits have outweighed the downsides)