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Diabetes Res Clin Pract 2012;98(2):271284

The results, despite optimistic interpretation by the sponsors, showed little if any cardiovascular benefit that could not have been a consequence of glucose lowering with some suggestion that the net effects of some agents might be harmful on vascular disease (6)

These prescription drugs work by targeting GLP-1 receptors, promoting feelings of fullness, reducing food intake, and regulating blood sugar levels

Future research should focus on mechanistic studies, long-term safety, and identifying biomarkers to predict dermatologic responses, ultimately guiding personalized treatment approaches

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Authors identified 51,408 adults with newly diagnosed type 2 diabetes and overweight or obesity who initiated treatment with either GLP-1 RAs (25,704 users) or SGLT2 inhibitors (25,704 users) following 1:1 propensity score matching to adjust for differences at baseline