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Boom in GLP-1 drugs augurs food industry disruption. Food Business News
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Furthermore, as for cardiac fibroblasts, GLP-1RAs inhibit Ang II and glucose-induced collagen formation via decreasing phospho-NF-B-p65 and phospho-ERK1/2 expression [169] (Figure 2)
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They reduce caspase-3 mRNA activity and enhance the expression of anti-apoptotic genes, including Bcl-2 and Bcl-xl [45, 46]
Because excess weight is closely linked to insulin resistance, fatty liver disease, sleep apnoea, cardiovascular disease, and progression to type 2 diabetes, weight loss achieved with GLP-1 therapy can have wide-ranging metabolic benefits even before diabetes develops
