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22 Compared with the control group, liraglutide also significantly increased activation of the dorsolateral prefrontal cortex and orbitofrontal cortex brain regions ( P = .0038)

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It was found that for subjects treated with its highest dose, the cardiovascular risk of tirzepatide treatment was a low risk of 0.5, with only 11 MACE being recorded as compared to 62 MACE with insulin glargine [26]

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