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Conclusion The GLP-1 RAs in people with obesity or type 2 diabetes are associated with a significant reduction in all-cause death, alongside an increased risk of pancreatic adverse eventsparticularly acute pancreatitismost pronounced during the first 6 months of treatment

GLP-1 receptor agonists do not increase the risk of hypoglycemia relative to placebo (48)

To enhance the safety of GLP-1-RAs in clinical practice, it is critical to carefully select patients and adequately manage gastrointestinal side effects, despite the medications' typically excellent tolerance [80]

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