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this result was observed regardless of baseline CV risk profile, with no significant differences between subgroups (p = 0.25 for interaction between subjects with prior MI or stroke vs no prior MI or stroke and p = 0.27 for interaction between subjects with established CVD vs CV risk factors only)

no changes were detected in the putamen ( t = 2.17, BF = 1.51) nucleus accumbens ( t = 2.19, BF = 1.58) (Fig
that is, NAMPT promotes SIRT1 activity through a NAD + pool increase and NAM level reduction
