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Conclusion Recent studies showed a strong association between oxidative stress and apoptosis in animal models as well as in SLE patients

Surprisingly, these phenotypic consequences of CBP/p300 inhibition did not result in viability defects in NRF2-dependent cell lines

M., Laskowski, D

One explanation is that while antioxidants can initially protect cells, prolonged exposure might deplete intracellular antioxidant reserves and make cells more susceptible to damage

Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, et al

Lehninger Principles of Biochemistry
