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It also activates GLP-1 and GIP receptors located in various organs, including the brain's appetite centers

Results were modulated by the apolipoprotein E (ApoE) genotype

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What began as a therapeutic advance in diabetes has evolved into a broader transformation of how metabolic diseases are treated and understood

If intolerable side effects occur during escalation, remain at current dose for an additional 4 weeks before attempting to increase, or drop back to the previous dose