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Gastrointestinal side effects such as nausea, vomiting, and diarrhoea are common with GLP-1 therapy and can be physically draining

GLP-1R agonism causes a small rise (usually 23 bpm) in heart rate (149), GIP infusion increases heart rate in humans (60) and GCGR agonism appears to have a positive chronotropic and inotropic action on the heart (150)

Gianni G, Pasqualetti M

It also plays an important role in supporting fat metabolism

Some of the emerging pathways under investigation in recent years include impaired upper-airway dilator tone, low arousal threshold, and ventilatory instability (elevated loop gain) [4, 5, 8,9,10,11,12,13,14]

If hed been asked that question 8 months ago, he would have waited 3, 4, 5, 6 or months to see if other treatments worked