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The problem is, there is no guarantee that the classes that emerge from the analysis correspond to clinically recognisable or reproducible subtypes

Andean Latin America, Oceania, and South-East Asia experienced the most significant rises in ASRs of smoking-attributable bladder cancer, whereas the largest decreases were observed in Western Europe, Australasia, and Southern Latin America (Supplementary file Table S1)

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IARC Monogr Eval Carcinog Risks Hum 1988;44:1378

Subsequently, the cut-off point of prevalence or probability of success was selected that yielded the highest efficiency values (highest percentage of correct classifications), together with the highest sensitivity value plus specificity