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[10] Signs and symptoms [edit] On average, exposures at 100 ppm or greater is dangerous to human health

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Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation
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EPCs have the biological characteristics of secreting vasoactive substances, proliferation, homing, and migration 2

This is also why longer holders were for more formal occasions, which often had more elaborate dress codes
