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ChemBioChem 24(3):e202200368

CFTR inhibition mimics the cystic fibrosis inflammatory profile

IL-8 has been identified as a transcriptional target for KRAS-mediated ERK or PI3K signal transduction, affecting endothelial cell recruitment, tumour-associated inflammation formation, and tumour angiogenesis 90,91

M.ManyesL.LucianoF.MaesJ.MecaG

In turn, the former can be generated via three mechanisms, namely, (i) oxidative deamination of alkaline amino acids (lysine, threonine, arginine and proline) by a radical-mediated mechanism

The compound sits within the pineal and AEDG peptide research area, alongside related bioregulator compounds studied for cellular signaling and regulatory function