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3.2 Mechanisms of resistance to membrane-targeting antifungals: polyenes and azoles 3.2.1 Polyene antifungal antibiotics interact with cell membrane sterols Polyene antifungal agentssuch as nystatin, AMB, and natamycinare broad-spectrum drugs commonly used to treat opportunistic fungal infections caused by Candida , Cryptococcus , Aspergillus , and Lentinus species (Carolus et al., 2020