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Furthermore, the alkaloid SZ-A, derived from mulberry twigs, enhances endothelial cell function and mitigates inflammatory responses by reducing CXCL-10 secretion from M1 macrophages, offering a novel therapeutic approach for atherosclerosis treatment (109)

TF neutralizes iron-induced toxicity in iRPE cells Because lipid peroxidation leads to iron overload in iRPE cells, we further investigated the mechanisms of action of TF on iRPE cells exposed to FeCl 3 associated with nitrilotriacetate, which forms a stable iron complex in solution

This is because all retinoids have to be converted to Tretinoin, AKA Retinoic Acid

doi: 10.1111/odi.13676 168 TwetmanS.DerawiB.KellerM.EkstrandK.Yucel-LindbergT.Stecksen-BlicksC

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These findings highlight that early-life Mn exposure has significant neurodevelopmental implications, with the developing brain being especially sensitive to Mn accumulation
