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In the context of a herniated disc, the surrounding spinal muscles often go into a state of chronic spasm and can even atrophy from disuse or nerve signal interruption

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Proteins 1997
Brain Res Bull 165:3039 Chen J, Zhou Y, Mueller-Steiner S et al (2005) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

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2.4.1 Basic science research Similarly, in the context of PD, mitochondrial dysfunction can drive neurodegeneration
