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Based on the currently accepted model for the OCTN2 carnitine transporter, 3,4 the novel missense mutations (R19P and R399Q) are located in intracellular domains of the protein with no recognized function

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Levels of another microRNA, miR-186, also are decreased through aging, and this microRNA targets 3-untranslated region (UTR) of BACE1 and is implicated in the mitigation of the oxidative stress effects in AD pathogenesis by suppression of BACE1 expression with resultant lower levels of A (449)

Updated 9/2022

Leslie, S

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