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The 10 antibodies including IgG-A and IgG-B purified by the standard method irreversibly aggregated after the concentration step (Table 2 and Fig
Adding the 9mg arm suggests the sponsor believes the 8mg to 12mg range contains the optimal therapeutic dose and wants more granular data to identify it precisely
J Hazard Mater 474:134727
J Alzheimers Dis 73: 723739, 2020
After incorporation of various mutations, later "superTEV protease" versions are highly active in the presence or absence of reducing agent
doi: 10.1084/jem.20041257 29 McGeachyMJChenYTatoCMLaurenceAJoyce-ShaikhBBlumenscheinWMet al
