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If not loaded correctly, B12 supplementation may not be sufficient

Significantly higher levels of 8-hydroxy-2-deoxyguanosine, which is the most profuse oxidation product in the purine base of DNA and is considered a marker of oxidative DNA damage, were detected in lenses with age-related cataracts compared to control subjects [26]

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Transgenic mice expressing human PON3 have been shown to be protected from the development of atherosclerosis, without any significant changes in plasma lipoprotein cholesterol, triglyceride or glucose levels