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Granzyme B is one of the most highly expressed proteins in effector CD8 T cells [2, 7, 33, 37, 42]

Mast cells, a potent contributor to the release of inflammatory mediators, including histamine, are identified in increased quantity in rosacea patients, and receptors for histamine and serotonin, leading to vasodilatory effects, are upregulated in all forms of rosacea

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FDA cannot properly cite EPAs lack of action to revise the RfC and address the new literature as evidence of the lack of new and significant studies

doi:10.1002/jor.20096 Cerovecki T, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, Sikiric P